Blar i forfatter "Nicol, Mark P."

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    • Composition of gut microbiota of children and adolescents with perinatal HIV infection taking antiretroviral therapy in Zimbabwe 

      Flygel, Trym Thune; Sovershaeva, Evgeniya; Classen-Weitz, Shantelle; Hjerde, Erik; Mwaikono, Kilaza S.; Odland, Jon Øyvind; Ferrand, Rashida A.; McHugh, Grace; Gutteberg, Tore Jarl; Nicol, Mark P.; Cavanagh, Jorunn Pauline; Flægstad, Trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-24)
      <p><i>Background - </i>Human immunodeficiency virus (HIV) infection causes impairment of the gastrointestinal barrier, with substantial depletion of CD4<sup>+</sup> T cells in the gut. Antiretroviral therapy (ART) restores CD4<sup>+</sup> counts and may have beneficial effects on gut microbiota in adults. Little is known about effect of long-term ART on gut microbiome in HIV-infected children. We ...

    • Effect of Once-Weekly Azithromycin vs Placebo in Children With HIV-Associated Chronic Lung Disease: The BREATHE Randomized Clinical Trial 

      Ferrand, Rashida A.; McHugh, Grace; Rehman, Andrea M.; Mujuru, Hilda A.; Simms, Victoria; Majonga, Edith D.; Nicol, Mark P.; Flægstad, Trond; Gutteberg, Tore Jarl; Gonzalez-Martinez, carmen; Corbett, Elizabeth L.; Rowland-Jones, Sarah; Kranzer, Katharina; Weiss, Helen Anne; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-17)
      <i>Importance</i> - HIV-associated chronic lung disease (HCLD) in children is associated with small airways disease, is common despite antiretroviral therapy (ART), and is associated with substantial morbidity. Azithromycin has antibiotic and immunomodulatory activity and may be effective in treating HCLD through reducing respiratory tract infections and inflammation.<p> <p><i>Objective</i> - ...

    • The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease 

      Abotsi, Regina E.; Nicol, Mark P.; McHugh, Grace; Simms, Victoria; Rehman, Andrea M.; Barthus, Charmaine; Ngwira, Lucky G.; Kwambana-Adams, Brenda; Heyderman, Robert S.; Odland, Jon Øyvind; Ferrand, Rashida A.; Dube, Felix S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-07)
      Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD. Nasopharyngeal (NP) swabs and sputa were ...

    • Prevalence and antimicrobial resistance profiles of respiratory microbial flora in African children with HIV-associated chronic lung disease 

      Abotsi, Regina E.; Nicol, Mark P.; McHugh, Grace; Simms, Victoria; Rehman, Andrea M.; Barthus, Charmaine; Mbhele, Slindile; Moyo, Brewster Wisdom; Ngwira, Lucky Gift; Mujuru, Hilda A.; Makamure, Beauty; Mayini, Justin; Odland, Jon Øyvind; Ferrand, Rashida A.; Dube, Felix S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-25)
      <b>Background</b> HIV-associated chronic lung disease (CLD) is common among children living with HIV (CLWH) in sub-Saharan Africa, including those on antiretroviral therapy (ART). However, the pathogenesis of CLD and its possible association with microbial determinants remain poorly understood. We investigated the prevalence, and antibiotic susceptibility of <i>Streptococcus pneumoniae </i>(SP), ...

    • Sputum bacterial load and bacterial composition correlate with lung function and are altered by long-term azithromycin treatment in children with HIV-associated chronic lung disease 

      Abotsi, Regina E.; Dube, Felix S.; Rehman, Andrea M.; Claassen-Weitz, Shantelle; Xia, Yao; Simms, Victoria; Mwaikono, Kilaza S.; Gardner-Lubbe, Sugnet; McHugh, Grace; Ngwira, Lucky G.; Kwambana-Adams, Brenda; Heyderman, Robert S.; Odland, Jon Øyvind; Ferrand, Rashida A.; Nicol, Mark P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)
      Background - Long-term azithromycin (AZM) treatment reduces the frequency of acute respiratory exacerbation in children and adolescents with HIV-associated chronic lung disease (HCLD). However, the impact of this treatment on the respiratory bacteriome is unknown.<p> <p>Method - African children with HCLD (defined as forced expiratory volume in 1 s z-score (FEV1z) less than − 1.0 with no ...